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Fig. 10 | Journal of Neuroinflammation

Fig. 10

From: Microglia-derived IL-1β contributes to axon development disorders and synaptic deficit through p38-MAPK signal pathway in septic neonatal rats

Fig. 10

IL-1β inhibits NFL, NFM and synaptophysin protein expression via activation of p38-MAPK signaling pathway in primary cultured cortical neurons. Panel (a) shows p38 phosphorylation and total p38 (38KDa) immunoreactive bands. Panels (b) is a bar graph depicting significant changes in the optical density of p38 phosphorylation at different time points following IL-1β administration (**P<0.01). Panels (c) shows NFM (160 kDa), NFL (68 kDa), and synaptophysin (38 kDa) immunoreactive bands, indicating that SB203580 (a p38 inhibitor) may reverse the reduction of NFM, NFL and synaptophysin expression after IL-1β administration. Bar graphs in (d, e, and f) show significant increase in expression of NFM, NFL and synaptophysin, respectively, by SB203580. (*P <0.05, **P<0.01)

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Journal of Neuroinflammation

ISSN: 1742-2094