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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Microglia-derived IL-1β contributes to axon development disorders and synaptic deficit through p38-MAPK signal pathway in septic neonatal rats

Fig. 4

LPS inhibits the maturation of oligodendrocytes in the PWM at 14 and 28d. af show PLP protein expression in the PWM at 14 and 28d after LPS injection and the matching controls. Immunofluorescene images showing the expression of PLP in the PWM at 14 and 28d of the LPS exposure (b, d) and corresponding control rats (a, c). e PLP (30 kDa) and β-actin (42 kDa) immunoreactive bands. Bar graph (f) shows significant reduction in the optical density of PLP following LPS exposure in comparison with the corresponding controls (*P < 0.01). In situ hybridization in (gk) showing the number of PLP+ oligodendrocytes in the PWM at 28 days after LPS exposure and the matching control. Panel (g, h) the number of PLP+ oligodendrocytes in the PWM under low microscopy (×10). Panel (i, j) the number of PLP+ oligodendrocytes in the PWM under high microscopy (×40). Bar graph (k) showing the number of PLP+ oligodendrocytes in the PWM. Note that the number of PLP+ oligodendrocytes in the PWM at 28 days after LPS exposure decreased significantly when compared with the corresponding controls (* P <0.01). Scale bars: ad 40 μm

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