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Table 1 Cytokines and chemokines are induced by Bb in glial cells of the CNS and significantly reduced by dexamethasone (when used at concentrations of 150 μM; p < 0.001), as evaluated in culture supernatants after 48 h. Meloxicam had no effect

From: Effects of dexamethasone and meloxicam on Borrelia burgdorferi-induced inflammation in glial and neuronal cells of the central nervous system

Rhesus astrocytes

Rhesus microglia

Human oligodendrocytes

Mediator pg/mL

Bb

Bb + dex

Mediator pg/mL

Bb

Bb + dex

Mediator pg/mL

Bb

Bb + dex

IL-1β

24

0

IL-1β

64 ± 10

0

IL-6

141 ± 1.2

65 ± 2.7

IL-2

146

21.8 ± 10

IL-2

268 ± 12

54

IL-8

1145 ± 609

97 ± 2.2

IL-6

27175 ± 2567

596 ± 51

IL-6

92562 ± 2979

1319 ± 77

CCL2

5691 ± 410

1898 ± 96

IL-8

113486 ± 882

1636 ± 40

IL-8

493804 ± 3550

3069 ± 309

 

IL-10

36

3.72

IL-10

40.45 ± 6.26

17.94

 

CCL2

76594 ± 1076

2442 ± 260

CCL2

256397 ± 2581

12415 ± 409

 

CCL3

95.43

0

CCL3

2948 ± 176

136 ± 10

 

CCL4

25.34

0

CCL4

183.64

0

 

VEGF

1220 ± 122

0

VEGF

3153 ± 108

941 ± 28

 

GMCSF

674 ± 20

0

GMCSF

3076 ± 127

501 ± 6.14

 
 

TNF-α

569 ± 45

0

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