Fig. 9

The effect of SB on PGE2 concentration in the brain after neonatal HI. Seven-day-old rats (PND7) were subjected to hypoxia-ischemia followed by 24 h and 6 days of recovery. SB or vehicle was administered directly after the onset of HI and for 5 consecutive days (determined by the experimental paradigm). The PGE2 concentration was determined in the ipsilateral (injured) hemispheres as well as in the control brains. Graphs represent statistical analysis of the data from indicated experimental groups: vehicle control (C), SB-treated control (C + SB), vehicle-treated hypoxia-ischemia (HI), and SB-treated hypoxia-ischemia (HI + SB). SB application had no effect on the HI-induced activation of PGE2 in the HI ipsilateral hemispheres. The values represent means ± SD from five animals in each group. The one-way ANOVA and Bonferroni test: *p < 0.05 and ***p < 0.001. C control, ipsi ipsilateral