Table 1 Clinical and MRI parameters at diagnosis and at the enrolment (whole population)

N (f/m)

50 (34/16)

40 (28/12)

90 (62/28)

0.511

Age (years)

42.5 ± 10.4 (19–67)

42.4 ± 11.2 (17–69)

42.5 ± 10.7 (17–69)

0.943

Years from onset to diagnosis

3.0 ± 5.1 (0–21)

2.6 ± 3.9 (0–17)

2.8 ± 4.6 (0–21)

0.356

Years from diagnosis to enrolment

7.8 ± 5.2 (0–20)

7.9 ± 6.4 (0–22)

7.9 ± 5.7 (0–22)

0.918

Years from onset to enrolment (disease duration)

10.8 ± 7.0 (1–31)

10.5 ± 7.3 (1–29)

10.7 ± 7.1 (1–31)

0.878

EDSS at diagnosis

1.5 (0–3.0)

1.0 (0–3.5)

1.5 (0–3.5)

0.645

EDSS at enrolment

2.8 (1.0–8.0)

1.5 (0–6.5)

2.0 (1.0–8.0)

<0.0001

RRMS/SPMS at enrolment

35/15

36/4

71/19

0.018

Time to SPMS transition in months

123 ± 23 (98–187)

183 ± 13 (165–198)

136 ± 33 (98–198)

<0.0001

Cognitive impairment CN/mCI/sCI

30/9/11

34/5/1

64/14/12

0.013

CL number at enrolment

6.1 ± 6.1 (0–24)

2.2 ± 2.8 (0–11)

4.4 ± 5.3 (0–24)

<0.0001

WMLV at enrolment (cm³)

7.1 ± 3.6 (1.1–16.4)

6.5 ± 4.1 (1.3–18.1)

6.8 ± 4.0 (1.1–18.1)

0.258

 None

0

5

5

0.033

 Only 1° line^a

34

28

62

 At least 2° line^a

11

6

17

 At least 3° line^a

5

1

6