Fig. 2From: Aprepitant limits in vivo neuroinflammatory responses in a rhesus model of Lyme neuroborreliosisAprepitant treatment prevents B. burgdorferi-induced increases in CCL2 protein levels in the CSF of NHPs. Rhesus macaques were uninfected (n = 5 animals) or infected intrathecally with B. burgdorferi (Bb, 1 × 108 bacteria; n = 15) and were untreated (n = 7) or treated with aprepitant (Ap, n = 8) for 2 (a) or 4 (b) weeks. Expression of CCL2 in CSF was determined by multiplex analysis. Data is expressed as the mean ± SD and asterisks indicate statistically significant differences between the untreated and treated groups (p < 0.05)Back to article page