Fig. 5
From: Aprepitant limits in vivo neuroinflammatory responses in a rhesus model of Lyme neuroborreliosis
Aprepitant treatment attenuates B. burgdorferi infection-induced reductions in astrocyte activity/numbers. Rhesus macaques were uninfected orx infected intrathecally with B. burgdorferi (Bb, 1 × 108 bacteria) and were untreated or treated with aprepitant (Ap) for 2 or 4 weeks prior to euthanasia. GFAP expression in frontal cortical tissue samples at 2 (a) and 4 (b) weeks following infection was determined by immunofluorescence microscopy. Relative GFAP expression in two fields of three sections from an animal in each group is shown and data is expressed as the mean ± SD. Asterisk and pound symbols indicate statistically significant difference from uninfected animals and untreated infected animals, respectively (p < 0.05)