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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Alleviation of secondary brain injury, posttraumatic inflammation, and brain edema formation by inhibition of factor XIIa

Fig. 3

Factor XII (FXII)-deficiency and pharmacologic inhibition of activated FXII inhibits degradation of tight junction protein occludin. Quantification of occludin by Western blot analysis on day 1 (d1, upper panel) and on day 3 (d3, lower panel) after injury in sham-operated animals, WT mice and FXII−/− mice (left), and sham-operated mice and mice treated with rHA-Infestin-4 or vehicle (right), respectively (n = 5 per group, **P < 0.01, *P < 0.05, one-way ANOVA followed by Bonferroni multiple comparison test compared with WT mice, AU arbitrary units)

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