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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Alleviation of secondary brain injury, posttraumatic inflammation, and brain edema formation by inhibition of factor XIIa

Fig. 5

a Determination of interleukin-1β (IL-1β) concentrations in the brain tissue of sham-operated mice, FXII−/− mice, and mice treated with rHA-Infestin-4 and their respective controls on day 1 after injury (n = 4–5 per group, ***P < 0.001, **P < 0.01, *P < 0.05, one-way ANOVA followed by Bonferroni multiple comparison test compared with WT mice). b Relative gene expression of IL-1β (lower panel) and tumor necrosis factor α (TNF-α, upper panel) in the injured cortices of rHA-Infestin-4- and vehicle-treated mice on day 1 (d1) and day 3 (d3) after trauma induction (n = 5 per group, **P < 0.01, *P < 0.05, unpaired, two-tailed Student’s t test, amount of gene expression normalized to sham-operated animals (not shown))

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