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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Alleviation of secondary brain injury, posttraumatic inflammation, and brain edema formation by inhibition of factor XIIa

Fig. 6

Factor XII enhances inflammatory processes after traumatic brain injury. a Neutrophils were quantified in the lesioned hemispheres after 1 (d1) and 3 days (d3) after brain trauma (left). Representative immunohistochemical stainings of neutrophils in FXII-deficient animals and wildtype mice on d1 (right). Scale bar depicts 50 μm (n = 4, **P < 0.01, *P < 0.05, unpaired, two-tailed Student’s t test). b Determination of ICAM-1 plasma concentrations of sham-operated mice, FXII−/− mice and mice treated with rHA-Infestin-4 and their respective controls on day 3 after injury (n = 4–5 per group, *P < 0.05, one-way ANOVA followed by Bonferroni multiple comparison test compared with WT mice). c Relative gene expression of ICAM-1 in FXII-deficient mice (left) and rHA-Infestin-4-treated mice (right) in comparison to their respective control groups 3 days after trauma induction (n = 5, ***P < 0.001, **P < 0.01, unpaired, two-tailed Student’s t test, amount of gene expression normalized to sham-operated animals (not shown))

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