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Table 1 Determination of bradykinin plasma level by ELISA 2 h after injury induction reveals a reduction of bradykinin in FXII−/− mice and animals treated with rHA-Infestin-4 similar to uninjured animals (Sham) when compared with injured wildtype (WT) and vehicle-treated mice (Vehicle) (n = 5 per group, **P < 0.01, *P < 0.05, one-way ANOVA followed with Bonferroni multiple comparison test and unpaired, two-tailed Student’s t test, respectively)

From: Alleviation of secondary brain injury, posttraumatic inflammation, and brain edema formation by inhibition of factor XIIa

  Sham WT FXII−/− Vehicle rHA-Infestin-4
Bradykinin concentration (pg/ml) 2099 ± 273 6591 ± 1324 1756 ± 766* 3294 ± 683 1405 ± 266#
  1. *P < 0.05 WT vs FXII−/−; # P < 0.05 Vehicle vs rHA-Infestin-4