Table 2 Cytokine release of APC during FTY treatment
APC subtype | Cytokine | MS CTRL | MS FTY | p value |
|---|---|---|---|---|
slanDC | IL-1beta | 13,992.8 (+/−3452.7) | 3762.3 (+/−1773.8) | <0.01 |
|  | IL-6 | 68,729.8 (+/−22,461.7) | 52,339.4 (+/−23,723.3) | n.s. |
|  | TNF-alpha | 41,189.0 (+/−7526.0) | 18,302.1 (+/−6363.5) | <0.05 |
|  | IL-12 | 484.9 (+/−99.3) | 179.7 (+/−44.6) | <0.05 |
|  | IL-23 | 3298.2 (+/−990.9) | 1304.6 (+/−326.2) | <0.05 |
CD1 + DC | IL-1beta | 405.1 (+/−48.3) | 255.7 (+/−57.4) | <0.05 |
|  | IL-6 | 7556.1 (+/−3401.0) | 5270.4 (+/−2260.8) | n.s. |
|  | TNF-alpha | 1190.7 (+/−289.7) | 653.1 (+/−19.6) | <0.05 |
|  | IL-12 | 166.1 (+/−54.0) | 182.3 (+/−42.9) | n.s. |
|  | IL-23 | 213.2 (+/−15.9) | 188.7 (+/−28.8) | n.s. |
Monocytes | IL-1beta | 6517.8 (+/−1073.1) | 4300.2 (+/−620.1) | <0.05 |
|  | IL-6 | 110,065.0 (+/−17,602.5) | 106,537.0 (+/−23,730.0) | n.s. |
|  | TNF-alpha | 9018.8 (+/−2753.8) | 4841.4 (+/−809.6) | <0.05 |