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Fig. 10 | Journal of Neuroinflammation

Fig. 10

From: Microglial-derived microparticles mediate neuroinflammation after traumatic brain injury

Fig. 10

MP isolated from CD11b-isolated microglia/macrophages following TBI increase neuroinflammation in the cortex of uninjured mice. CD11b-microglia/macrophages in the cortex of sham and TBI were isolated at 7 days post-injury and cultured for 24 h prior to collecting MP. Enriched MP were stereotactically injected into the cortex of adult male C57BL/6 mice and markers of cortical neuroinflammation were measured at 24 h postinjection. There was a significant increase in pro-inflammatory mediators (IL-1β and TNF-α) in the cortex of the control MP-injected group (***p < 0.001 vs naïve group). When compared to the control MP-injected group, there was a further significant increase in pro-inflammatory mediators (IL-1β, TNF-α, and miR-155) in the cortex of the TBI MP-injected group (^p < 0.05, ^^p < 0.01, ^^^p < 0.001 vs control MP-injected group; one-way ANOVA with Student-Newman-Keuls correction for multiple comparisons; n = 5/group). Bars represent mean ± S.E.M.

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