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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Microglial-derived microparticles mediate neuroinflammation after traumatic brain injury

Fig. 3

Circulating blood MP released after TBI activate naive BV2 microglia. Enriched MP were isolated from the blood of sham-injured and TBI mice and were co-cultured with naïve BV2 microglia cells for 24 h. Microglial receptors (P2X7) and pro-inflammatory mediators (IL-1β and CCL2) were significantly increased in BV2 microglia treated with circulating TBI MP (*p < 0.05 and ***p < 0.001 vs naïve; ^p < 0.05 and ^^p < 0.01 vs sham MP; one-way ANOVA with Student-Newman-Keuls correction for multiple comparisons; n = 6/group). There were no significant differences in TNF-α, NOS2, IL-6, and miR-155 expression between treatment groups. Bars represent mean ± S.E.M.

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