Fig. 6

Lipopolysaccharide-stimulated MP activate primary cortical microglia. Enriched MP were isolated from control and LPS-stimulated BV2 microglia and were co-cultured with primary cortical microglia for 24 h. Pro-inflammatory mediators (IL-1β, TNF-α, miR-155, IL-6, CCL2, and NOS2) were significantly increased in primary microglia treated with LPS MP (*p < 0.05, **p < 0.001, and ***p < 0.001 vs naïve; ^p < 0.05 and ^^p < 0.01 vs control MP; one-way ANOVA with Student-Newman-Keuls correction for multiple comparisons; n = 5/group). Bars represent mean ± S.E.M.