Fig. 4

Cytokine production and macular fibrosis. CCL2, IL-8 and VEGF levels in PBMC supernatants under non-stimulated condition (a), following LPS treatment (b) and under hypoxic condition (c) as well as percentage of total IL-8 producing PBMCs under non-stimulated conditions (d) from healthy controls and nAMD patients without and with fibrosis. Supernatants: controls, n = 28, fibrosis (−), n = 54, fibrosis (+), n = 21; PBMC: controls, n = 27, fibrosis (−), n = 15, fibrosis (+), n = 13; mean + SEM; #P < 0.05, ##P < 0.01, ###P < 0.001 in univariate analysis using one-way ANOVA; *P < 0.05, **P < 0.01 in multivariate analysis using multinomial logistic regression