Fig. 1

Piglet brain metabolic changes following hypoxia-ischemia injury. a Location of ¹H MRS voxels superimposed on coronal 9.4 T brain MR images of a term piglet. The midparietal plane shows the location of the voxels on the basal ganglia and dorsal subcortical white matter forebrain regions. b Representative ¹H MRS in the dorsal subcortical voxel of neonatal piglets with poor outcome 48 h after HI. Note the substantial increase in the lactate peak (Lac) and reduction of NAA. The creatine peak remains moderately unchanged. c Representative ¹H MRS of a newborn piglet with normal neurodevelopmental outcome at 48 h of age. Note the absence of a lactate peak