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Table 3 Correlation of piglet neonatal serum cytokine levels with cerebral metabolite ratios assessed by proton-MRS

From: Systemic pro-inflammatory cytokine status following therapeutic hypothermia in a piglet hypoxia-ischemia model

Cytokines Lac/NAA Naa/Cr Lac/Cr
Basal ganglia White matter Basal ganglia White matter Basal ganglia White matter
Coef p Value Coef p Value Coef p Value Coef p Value Coef p Value Coef p Value
IL-1β 0.51 <0.001 0.42 0.003 −0.33 0.02 −0.31 0.004 0.51 <0.001 0.4 0.005
IL-4 −0.01 0.96 0.06 0.71 0.22 0.13 0.18 0.24 0.06 0.68 0.15 0.30
IL-6 0.02 0.87 0.15 0.30 0.18 0.21 0.06 0.71 0.09 0.55 0.22 0.14
IL-8 0.25 0.09 0.28 0.05 −0.18 0.21 −0.23 0.12 0.23 0.11 0.25 0.10
IL-10 0.46 <0.001 0.50 <0.001 −0.37 0.01 −0.40 0.005 0.42 0.003 0.46 0.001
TNF-α 0.13 0.38 0.09 0.53 0.02 0.88 −0.01 0.93 0.17 0.25 0.07 0.63
  1. Bold p values indicate significance at p < 0.05
  2. Statistical association based on Spearman’s rank correlation