Fig. 1

LPS effects on astrocytosis in the PFC of WT and PTN-Tg mice. Photomicrographs are from GFAP-immunostained PFC sections of saline + saline (Sal)- or saline + LPS (LPS)-treated animals (n = 4–5/group). Higher magnification images in the lower right corner of every representative picture show that astrocytes were hypertrophic and densely stained in WT mice treated with LPS. The graph represents quantification of data obtained from the counts of GFAP-positive cells in PFC whole sections. ^## P < 0.01 vs. WT-LPS. Scale bar = 500 μm, (high magnification, scale bar = 50 μm). SAL saline, LPS lipopolysaccharide, WT wild-type mice, PTN-Tg mice with transgenic pleiotrophin overexpression in the brain, GFAP glial fibrillary acidic protein