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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Pleiotrophin regulates microglia-mediated neuroinflammation

Fig. 2

Effects of TAK-242 and LPS on microglia activation in the PFC of PTN-Tg mice. Photomicrographs are from Iba-1-immunostained PFC sections of saline (Sal)- or TAK-242 (TAK)-pretreated and saline (Sal)- or LPS-treated animals (n = 4–5/group) (a). Graphs represent quantification of data (mean ± SEM) obtained from the counts of Iba-1-positive cells (b), total marked area (c), cell area (d), soma perimeter (e), and circularity index (f) in PFC whole sections. *P < 0.05, ***P < 0.001, ****P < 0.0001 vs. Sal + Sal within the same genotype. # P < 0.05, ## P < 0.01 vs. WT within the same treatment. Scale bar = 100 μm. SAL saline, LPS lipopolysaccharide, TAK TAK-242, WT wild-type mice, PTN-Tg mice with transgenic pleiotrophin overexpression in the brain, Iba1 ionized calcium-binding adaptor molecule 1

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