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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Pleiotrophin regulates microglia-mediated neuroinflammation

Fig. 3

Effects of TAK-242 and LPS on cytokine expression in the PFC of PTN-Tg mice. TNF-α, Il-1β, IL-6, MCP-1, IL-4, and IL-10 protein levels measured using a Milliplex system in PFC of mice pretreated with saline (Sal) or TAK-242 (TAK) and treated with saline (Sal) or LPS (n = 5/group). *P < 0.05, ***P < 0.001 vs. Sal + Sal within the same genotype. ## P < 0.01, ### P < 0.001 vs. WT within the same treatment. &&P < 0.01, &&&P < 0.001 vs. Sal + LPS within the same genotype. SAL saline, LPS lipopolysaccharide, TAK TAK-242, WT wild-type mice, PTN-Tg mice with transgenic pleiotrophin overexpression in the brain, TNF Tumor necrosis factor-α, IL-1β interleukin 1β, IL-6 interleukin 6, MCP-1 monocyte chemoattractant protein-1, IL-4 interleukin 4, IL-10 interleukin 10

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