Astrocyte-specific overexpressed gene signatures in response to methamphetamine exposure in vitro

Table 4 Genes that are present in the highest represented pathways upregulated by Meth in astrocytes

Genes in the neuroactive ligand-receptor Interaction Pathway	Fold change in 10 μM/control	Genes in cytokine-cytokine receptor interaction pathway	Fold change in 10 μM/control
PTGER3	27.56	CCL27	27.51
GLRA2	15.51	CXCL11	12.83
PTGDR	11.97	IFNG	12.46
AGTR2	10.44	CXCL10	10.82
MAS1	8.37	CCL15	10.54
GH2	7.37	IL2RG	10.02
TBXA2R	6.30	XCL1	8.61
TSHR	6.27	GH2	7.37
HRH4	6.00	IL1RN	6.42
TACR3	5.19	IL18RAP	6.14
OPRK1	4.91	CXCL5	28.57
GNRHR	4.91	IL21	5.35
PLG	4.70	EPOR	5.05
		CSF2	5.04

DAVID was utilized for identification of pathways with important gene representation in changes induced by Meth and the genes within pathways that change as a result of Meth exposure on astrocytes

ISSN: 1742-2094