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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Macrophage and nerve interaction in endometriosis

Fig. 2

Macrophages regulate neurogenesis after peripheral nerve injury. After peripheral nerve injury happens in endometriosis, macrophages are firstly attracted to the lesion by CCL-2 secreted from Schwann cells. After the clearance of neural debris, M1 macrophages polarize toward M2 phenotype mediated by the CCL-2 and IL-10 in the milieus. M2 macrophages release VEGF-A, promoting the formation of blood vessels. After that, the Schwann cells migrate through the lesion along the blood vessels and then guide the axonal regeneration. Therefore, the regeneration of neurites is initiated and mediated by activities of macrophages. CCL-2: chemokine (C–C motif) ligand 2; IL-10: interleukin 10; VEGF-A: vascular endothelial growth factor A

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