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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Relationship of acute axonal damage, Wallerian degeneration, and clinical disability in multiple sclerosis

Fig. 1

Wallerian degeneration is most frequent in the PPWM of lesions with ongoing demyelinating activity. NPY-Y1R IHC was performed on multiple sclerosis biopsy and autopsy tissue samples containing active, early inactive, chronic active, and chronic inactive lesions (a–e). Double IHC of NPY-Y1R (red, a) with the pan-macrophage marker KiM1P (blue, a) showed very little evidence for Wallerian degeneration (arrows) in the actively demyelinating lesion edge of a multiple sclerosis biopsy (a, inset). The density of NPY-Y1R+ axonal profiles indicating Wallerian degeneration was significantly higher in PPWM areas of active and chronic active lesions compared to early inactive and chronic inactive lesions in both early and chronic multiple sclerosis patients (f). Significantly higher numbers of NPY-Y1R+ axonal profiles (arrows) were detected in the PPWM of early multiple sclerosis patients (biopsies; a–b, f) compared to chronic multiple sclerosis patients (autopsies; c–f). Error bars=SEM, *p < 0.05, **p < 0.01, ***p < 0.001. Scale bars; a 100 μm; b 25 μm, c–e 50 μm; (inset a, e) 10 μm

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