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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Relationship of acute axonal damage, Wallerian degeneration, and clinical disability in multiple sclerosis

Fig. 4

Similar extent of acute axonal damage but markedly reduced Wallerian degeneration in Wld S mice with acute EAE. Comparable densities of APP+ axonal profiles were found in spinal EAE lesions of Wld S and WT mice in both the acute and chronic disease stage (a–e). In contrast, significantly fewer NPY-Y1R+ axonal profiles were observed in Wld S as compared to WT mice in acute EAE (f–g and j). In the chronic stage, the densities of NPY-Y1R-immunoreactive axonal profiles were comparable between Wld S and WT mice (h–j). Error bars=SEM, *p < 0.05, n = 15 animals per group. Scale bars=(a–b) 100 μm; (inset b) 50 μm; (c–d) 200 μm; (f–g) 150 μm; (h–i) 200 μm

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