Fig. 7

miR-142a-3p and miR-142a-5p target gene expression in EAE tissue and human MS brain samples. miR-142a-3p target gene, TGFBR1, was significantly increased in peak of disease and post peak phase of EAE in spinal cord (a). SOCS1 and TGFBR2 were significantly decreased in peak of disease and post peak phases of EAE in comparison with pre-onset phase (b). In human autopsy samples, SOCS1 showed significant reduction in MS samples but the levels of TGFBR1 and TGFBR2 did not differ between MS and control tissues (c). Data are shown as mean ± SEM, **p < 0.01, *p < 0.05, one-way ANOVA