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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Lymphocytes have a role in protection, but not in pathogenesis, during La Crosse Virus infection in mice

Fig. 5

Adult Rag1 -/- and μMT -/- mice have increased susceptibility to LACV infection. ad Adult (6–8 weeks old) wildtype, Rag1 -/-, and μMT -/- mice were infected with 103 PFU of LACV and examined for a development of neurological disease, b, c virus RNA levels in the b brain and c spleen as well as the production of d neutralizing antibodies. a Data are presented as survival curve analysis of wildtype (n = 37), Rag1 -/- (n = 5), and μMT -/- (n = 12) mice. Statistical analysis was completed using the Mantel-Cox log-rank test. *** P <0.01. b, c RNA isolated from wildtype, Rag1 -/-, and μMT -/- mice at 10–12 dpi was assayed for LACV RNA by real-time PCR. Data were analyzed as described in “Methods” and are presented as a ratio of expression relative to housekeeping gene for each sample. Each symbol represents an individual mouse. d Neutralizing antibodies were detected at 5–10 dpi in wildtype mice. Data are presented as the dilution of plasma resulting in 50% inhibition of virus infection on a log2 scale. No detectable neutralizing antibodies were observed in Rag1 -/- or μMT -/- mice

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