Fig. 3
From: Proteomic analysis of aged microglia: shifts in transcription, bioenergetics, and nutrient response
RICTOR is upstream of multiple canonical pathways. a RICTOR and its downstream proteins displayed as a network. Symbol color represents expression value, red indicating an upregulation and blue/green indicating downregulation in our dataset. RICTOR modulates the expression or function of downstream proteins listed in figure. The aggregate expression values of data set proteins contribute to a predicted decrease in RICTOR activity. b Proteins downstream of RICTOR can be grouped into five canonical pathway groups and four families. The identified pathways are also included in the top five pathways identified as affected by age