Table 1 Functional processes identified from proteins differentially expressed with age
From: Proteomic analysis of aged microglia: shifts in transcription, bioenergetics, and nutrient response
Upregulated | Downregulated |
|---|---|
Oxidative phosphorylation—UQCRC2, NDUFB3, ATP5D, TCIRG1, UQCRC1, COX7A2, NDUFA7, ATP5F1, COX4I1, COX6C, SDHA, ATP6V1C1, ATP6V1A, NDUFS5, COX6B1, ATP6V0D1 | Spliceosome—NCBP1, TCERG1, PRPF8, U2AF2, TRA2B, SNRNP200, PRPF3, HNRNPC, DDX5, HNRNPU, SF3B2, SNRPG, PRPF40A |
Oxidoreductase—HSD17B11, UQCRC2, HSD17B10, CYB5R1, ME2, GLUD1, PGD, OGDH, PRDX1, FTH1, HADHA, ACOX3, IVD, CAT, COX7A2, ACADS, COX4I1, CBR4, TECR, COX6C, SOD2, SDHA, DHRS1, CYBA, BLVRB | Nuclear lumen—LMNB1, MTA2, PRPF3, DDX5, CBX5, HNRNPL, NONO, SET, TCERG1, HNRNPH2, ILF2, FRG1, PRPF8, ANP32A, RRS1, ACTL6A, RUVBL1, HNRNPH1, RBM14, LBR, PRPF40A, SMARCA4 |
Mitochondrion—UQCRC2, ATP5D, UQCRC1, COX7A2, ME2, GATM, ACADS, GLUD1, ATP5F1, ECHS1, COX4I1, OGDH, HADHA, HADHB, SOD2, SDHA, ACOT9, IVD, OXCT1, ATPIF1, HMGCL | Helicase activity—DDX17, SNRNP200, RUVBL1, DDX5, CHD4, SMARCA4 |
Hydrogen ion transmembrane transporter activity—TCIRG1, ATP5D, ATP6V1C1, ATP6V1A, COX7A2, COX6B1, ATP5F1, COX4I1, ATP6V0D1, COX6C | Nucleotide binding—RAB5B, TRA2B, U2AF2, HNRNPL, GPD1L, NONO, HSPH1, DDX17, AGPS, TARDBP, TUBB5, ACTL6A, HNRNPC, CHD4, CSTF2, STK24, ELAVL1, ATP1A1, DDX5, CRYZ, HNRNPR, HNRNPH2, ILF2, MAPK14, PSMC1, SNRNP200, RUVBL1, RBM14, SMC1A, HNRNPH1, SMARCA4, MDH1 |
Regulation of actin cytoskeleton organization—DBNL, CORO1A, ARPC3, ARPC2, CAPG, MYO1F, ARPC5, CAPZB | Chromatin organization—SET, SMARCD2, HIST1H1B, MTA2, SMARCC2, ACTL6A, RUVBL1, RBM14, CHD4, CBX5, SMARCA4 |
Lysosome—LAMP1, NPC1, CTSZ, LAMP2, LIPA, HEXA, HEXB, ARL8A, ACP2, CTSB, ARL8B, SCARB2 | Regulation of transcription—SUB1, MTA2, TERF2IP, DDX5, CBX5, NONO, FUBP3, TCERG1, SMARCD2, ILF2, HNRNPUL1, TARDBP, MAPK14, SMARCC2, ANP32A, ACTL6A, RUVBL1, RBM14, CHD4, SMARCA4 |
Generation of precursor metabolites and energy—UQCRC2, NDUFB3, ATP5D, TCIRG1, UQCRC1, NDUFA7, ATP5F1, HK2, OGDH, SOD2, SDHA, ATP6V1C1, ATP6V1A, CYBA, NDUFS5, GOT1, CAT, ATP6V0D1 | Nucleocytoplasmic transport—NCBP1, KPNA6, NUTF2, IPO9, KPNA3 |
Valine, leucine, and isoleucine degradation—HSD17B10, ACADS, IVD, OXCT1, ECHS1, HMGCL, HADHA, HADHB | Proteasome complex—PSMB4, PSMA6, PSMC1 |
Response to oxidative stress—GATM, APOE, CAT, GCLM, PRDX1, SOD2 | DNA repair—NONO, DDB1, SMC1A, APEX1 |
Immune effector process—PTPRC, CD47, MYO1F, FCER1G, INPP5D, PRDX1 | Coenzyme binding—GPD1L, DBT, AGPS, CRYZ, MDH1 |
Cell chemotaxis—CORO1A, FCER1G, NUP85 | Chromatin remodeling complex—MTA2, ACTL6A, CBX5, SMARCA4 |
Antigen processing and presentation of peptide antigen via MHC class I—H2-D1, FCER1G, B2M, TAPBP |  |
Apoptotic mitochondrial changes—SH3GLB1, BAX, SOD2 |  |
Cellular lipid catabolic process—HEXA, PLCG2, HEXB, HADHA, ACOX3, HADHB |  |