Fig. 4

The effects of Sirt1 overexpression on regulation of p-ERK/p-JNK/p-p38 in vitro and in vivo. a Overexpression of Sirt1 upregulates p-ERK and downregulates p-JNK and p-p38 compared to transfection control in vitro. n = 6/group, **P < 0.01 vs. the control group; ^# P < 0.05 vs. IL-1β-con. b Elevated Sirt1 expression increased ERK activation and decreased JNK and p-38 activation in vivo. n = 6/group, **P < 0.01 vs. the sham group; ^# P < 0.05 and ^## P < 0.01 vs. the DMSO group