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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Interactions between Sirt1 and MAPKs regulate astrocyte activation induced by brain injury in vitro and in vivo

Fig. 8

The possible interactions between Sirt1 and ERK, JNK, or p38MAPK pathway in traumatic brain injury. The brain injury reduced endogenous Sirt1 level and activated ERK, JNK, and p38MAPK pathways. Overexpressed Sirt1 attenuated astrocyte activation and decreased ERK, JNK, and p38MAPK activation. Inhibition of ERK, JNK, or p38MAPK activation increased Sirt1 expression and attenuated astrocyte activation

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Journal of Neuroinflammation

ISSN: 1742-2094