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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Amelioration of experimental autoimmune encephalomyelitis by clozapine is not associated with defective CD4 T cell responses

Fig. 1

Clozapine delayed the onset and reduced disease severity of EAE but did not alter antigen-specific T cell expansion. Mice were treated with clozapine or vehicle 1 day prior to EAE induction and scored daily (0: normal to 5: moribund). a Disease course of mice. b Disease onset. c Peak disease score. d Disease burden assessed by area under the curve analysis. Shown are the means and SEM of individual mice from two experiments combined (n = 10 mice/group). ****p < 0.0001 by Mann-Whitney test

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