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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes

Fig. 1

Selective attenuation of proinflammatory cytokines by MW150 administration in APP/PS1 KI mice cortex. a 11–12-month-old wild type (WT) or APP/PS1 knock-in (KI) mice were treated with saline vehicle (veh) or 2.5 mg/kg MW150 by intraperitoneal injection (i.p.) once daily for 14 days. b IL-1β was increased in KI + veh mice compared to WT + veh mice (p = 0.0012), and MW150 treatment of KI mice (KI + MW150) significantly attenuated IL-1β levels compared to KI + veh (p = 0.0243) (F(2,38) = 6.46; p = 0.004). c TNFα was elevated in KI + veh mice compared to WT + veh and attenuated in KI + MW150 mice compared to KI + veh; however, these changes were not significant (F(2,38) = 1.11; p = 0.34). d IL-6 was slightly elevated in KI + veh compared to WT + veh mice, and there was no effect of MW150 treatment (n = 11 WT + veh; n = 14 KI + veh; n = 14 KI + MW150). Data are mean ± SEM. Source data is available in Additional file 1: Table S1

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