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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes

Fig. 4

No effect of MW150 on CD45 and CD68 immunostaining in the cortex. a Representative images of CD45 IHC in cortex of wild type (WT) or APP/PS1 KI mice treated with saline vehicle (veh) or MW150. Digital quantification of CD45 in the cortex was done using the Aperio ScanScope, and the positive pixel algorithm. b CD45 was significantly increased in the KI + veh compared to the WT + veh treated mice (p < 0.0001), with no effect of MW150 treatment. (F(2,42) = 211.08; p < 0.0001). c Representative images of CD68 IHC. d CD68 was significantly increased in the KI + veh compared to the WT + veh-treated mice (p < 0.0001), with no effect of MW150 treatment. (F(2,42) = 28.81; p < 0.0001). (n = 14 WT + veh; n = 14 KI + veh; n = 14 KI + MW150). Data are mean ± SEM. Source data is available in Additional file 2: Table S2

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