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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Cytokine cascades induced by mechanical trauma injury alter voltage-gated sodium channel activity in intact cortical neurons

Fig. 2

Exposure to trauma-conditioned medium increases density of Na+ currents. a Representative recording of whole-cell currents in presence or absence of TTX (100 nM). b–d Recording of whole-cell Na+ currents from −100 to 100 mV in untreated control neurons and neurons exposed to medium conditioned for 24 h (with or without BDNF supplementation). e and f Relationship of current density and voltage in control and trauma-conditioned medium for 6 or 24 h treatment [with or without BDNF (30 ng/ml)]. g Changes in peak of current density are shown in control neurons and neurons exposed to conditioned medium for 6 or 24 h by injured mixed cultures (with or without BDNF supplementation). Values indicate mean ± SEM of three separate experiments. *p < 0.05; **p < 0.01 (one-way ANOVA with Tukey’s post hoc test). h Current–density–voltage relationship in control exposed to conditioned medium for 24 h and exposed to conditioned medium for 24 h with BDNF (1, 5, 10, 50, and 100 ng/mL). i Concentration-dependent effects of BDNF (0.01–100 ng/mL) on Na+ current density (IC50 = 43.33 ng/mL)

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