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Table 2 Effects of trauma-conditioned media and addition of BDNF on Na+ channel kinetics in neurons

From: Cytokine cascades induced by mechanical trauma injury alter voltage-gated sodium channel activity in intact cortical neurons

 

Activation

Inactivation

 

Control (n = 9)

Trauma (n = 9)

Trauma + BDNF (n = 8)

Control (n = 8)

Trauma (n = 10)

Trauma + BDNF (n = 8)

V 1/2 (mV)

−33.45 ± 0.48

−32.63 ± 0.57

−34.70 ± 0.44#

−52.47 ± 0.47

−54.56 ± 0.32**

−53.40 ± 0.34

k

4.19 ± 0.41

4.18 ± 0.50

3.29 ± 0.40

5.26 ± 0.47

5.60 ± 0.28

5.07 ± 0.29

  1. Trauma (24 h) and trauma + BDNF (24 h). Values indicate mean ± SEM
  2. V 1/2 voltage of half-maximal activation or inactivation, k slope factor
  3. **p < 0. 01 versus control; # p < 0.05 versus trauma (24 h) group (one-way ANOVA with Tukey’s post hoc test)
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Journal of Neuroinflammation

ISSN: 1742-2094