Fig. 4
From: Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome suppression
Procyanidins suppressed NLRP3 inflammasome activation in ankle periarticular tissue. Mice were treated with various doses of procyanidins (15, 30, and 60 mg/kg, PO) 20 min before the injection of MSU crystals (0.5 mg/10 μL). Western blot samples were collected 24 h after MSU injection (n = 4). Expression of pro- and cleaved IL-1β (a), pro- and cleaved caspase-1 (b), and NLRP3 (c) in ankle periarticular tissue are shown. *p < 0.05, **p < 0.01, ***p < 0.001 vs. normal; # p < 0.05, ## p < 0.01, ### p < 0.001 vs. the MSU-treated group