Fig. 2
From: Diffusion MRI quantifies early axonal loss in the presence of nerve swelling
DTI- and DBSI-derived parametric maps of one representative EAE optic nerve (eye 1) from baseline (top row), time 1 (middle row, onset), and time 2 (bottom row, onset of the fellow eye). Decreased axial diffusivity (λǁ, columns 1 and 2) and increased radial diffusivity (λ⊥, columns 3 and 4) in both DTI and DBSI measurements suggest axonal injury and demyelination at time 2. DBSI distinguished and further quantified the extent of inflammatory cell infiltration (column 5, restricted diffusion fraction) and vasogenic edema (column 6, non-restricted diffusion fraction), confounding DTI estimated λǁ and λ⊥