Fig. 2
From: The involvement of mast cells in the irinotecan-induced enteric neurons loss and reactive gliosis
Effects of the mast cells pre-degranulation in the intestinal histopathological analysis and villus height: duodenum, jejunum, and ileum of controls (untreated); animals with CPT-11-induced intestinal mucositis; pretreated with c48/80 and submitted to CPT-11-induced intestinal mucositis or treated only with c48/80. d – f CPT-11 induces shortening of the villus (green arrows), loss of crypt architecture (brown arrows), intense inflammatory cell infiltrate (blue arrows), and cell vacuolization (black arrows) in duodenum, jejunum, and ileum. Hematoxylin and eosin; scale bar correspond to 100 μm in all figures (a–l). Segments of duodenum (m), jejunum (n), and ileum (o) were collected for measurement of villus height (ten villus/slide). Bars represent mean ± SEM of eight mice in each group. # p < 0.05 versus control group, *p < 0.05 versus CPT-11 group. One-way ANOVA followed by Bonferroni