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Table 2 Histological scores for intestinal mucositis

From: The involvement of mast cells in the irinotecan-induced enteric neurons loss and reactive gliosis

Intestine segments

Experimental groups

Control

CPT-11

CPT-11 + c48/80

c48/80

Duodenum

0 (0–0)

4 (2–4)#

2 (1–3)#

0 (0–1)*

Jejunum

0 (0–0)

4 (3–4)#

2 (0–4)#*

0 (0–1)*

Ileum

0 (0–0)

4 (2–4)#

4 (3–4)#

0 (0–0)*

  1. Data represent median values (and range) of scores from 0 to 4 according to the presence of necrotic cells, loss of crypt architecture, shortened villi, and hypertrophy/hyperbasophilic in the crypt cells. Data were analyzed by using Kruskal–Wallis and Dunn’s test (n = 8). # p < 0.05 versus control group, *p < 0.05 versus CPT-11 group
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Journal of Neuroinflammation

ISSN: 1742-2094