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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Microglial depletion alters the brain neuroimmune response to acute binge ethanol withdrawal

Fig. 8

Effects of acute binge ethanol and microglial depletion on brain neuroimmune gene expression. a Acute binge ethanol causes biphasic changes in microglial gene expression. Various microglial genes such as Iba1 and CD68 decrease during acute intoxication. Later, during withdrawal, expression of these genes increases. These data suggest the effects of ethanol on microglia depend on time after exposure. b Microglial depletion alters brain gene expression. Various microglial genes, such as Iba1, decrease with microglial depletion. Other neuroimmune genes, such as TNFα or TGFβ1, also decrease. However, some neuroimmune genes, such as IL-1β, IL-6, and TLR4, do not decrease, suggesting these may be predominantly expressed in other cell types. Other genes, such as C3 and GFAP, increase with microglial depletion. c Microglia mediate a balance between pro- and anti-inflammatory gene expression during acute binge ethanol withdrawal. Microglial depletion blocks withdrawal-induced pro-inflammatory gene induction (TNFα and Ccl2). However, microglial depletion enhances withdrawal-induced anti-inflammatory gene induction (IL-1ra and IL-4)

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