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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Toll-like receptor 4 in glial inflammatory responses to air pollution in vitro and in vivo

Fig. 3

GO processes for nPM responses, analyzed by significance analysis of microarrays (SAM). a nPM-increased RNAs: (920), clustered into networks. Note the single node of NF-κB regulation, and TLR signaling pathway network. The cellular migratory network was condensed from 13 nodes to 5. Migratory pathways for T cells and other leukocytes identified by GO analysis are not depicted. b nPM-decreased RNAs (1076): Although 17% more RNAs were decreased than the increases, there were fewer enriched pathways. p < 0.00001. Colors denote different networks. Nodes with two colors belong to both networks. Each network has one highlighted node (colored text, chosen by experimenter) that best represents network function. The circle size represents the number of genes enriched in the node. The width of connecting lines represents the strength of connectivity between nodes, as measured by kappa score

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