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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Toll-like receptor 4 in glial inflammatory responses to air pollution in vitro and in vivo

Fig. 4

Weighted gene network co-expression analysis (WGCNA) of nPM and LPS responses, grouped as modules. a Dendrogram using hierarchical clustering to group genes by lowest values generated by a dissimilarity matrix. b Modules, color labeled for each gene (arbitrary colors), with modules placed by highest similarity between gene clusters. 45 modules were generated by WGCNA. c Statistical significance of each weighted gene co-expression network analysis (WGCNA) module, for nPM, LPS, and shared responses. Module colors from Fig. 4b are in the leftmost column (Mod). Modules from Fig. 3 with significant change (p < 0.01) are denoted by *. Of these 45 modules, 38 were enriched in the nPM subset, 4 in LPS subset, and 2 in the shared subset. Shared modules, which will be further analyzed for pathway enrichment, are marked by arrows. Scale bar is correlation coefficients between module eigengene and treatment condition. d Normalized fold change of RNA for each gene from nPM and LPS responses, respectively: red, increases; blue, decreases. Upper left, expanded section of b and c

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