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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Toll-like receptor 4 in glial inflammatory responses to air pollution in vitro and in vivo

Fig. 8

TLR4 pathway activation in mixed glia. Mixed glia: nPM increased mRNAs in the MyD88-dependent TLR4 signaling pathway. Media groups are non-transfected cultures. All values are given as log2 fold change. a MyD88 was increased by both nPM and LPS (p < 0.05), with no change observed in TLR4 siRNA-treated cultures. b TRAFD1 mRNA was increased by nPM treatment (p < 0.0001) and by LPS treatment (p < 0.0001), and rescued by siRNA treatment (p < 0.0001). c NF-κB mRNA was increased by nPM treatment (p < 0.01), and rescued by siRNA treatment (p < 0.05). d TNFα mRNA was induced by nPM treatment (p < 0.0001). siRNA treatment reduced nPM induction of TNFα mRNA (p < 0.0001). e JAK2 mRNA was increased by nPM and LPS treatment (p < 0.0001), and rescued by siRNA treatment (p < 0.0001). f STAT1 mRNA was increased by nPM and LPS treatment (p < 0.01 and p < 0.0001, respectively), and rescued by siRNA treatment (p < 0.05)

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