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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: The PD-1: PD-L1 pathway promotes development of brain-resident memory T cells following acute viral encephalitis

Fig. 3

The PD-1: PD-L1 pathway promotes establishment of bTRM cells following MCMV infection. Infected WT and PD-1 KO mice were sacrificed and brain mononuclear cells were collected at indicated time points. Flow cytometric analysis of CD8-gated T cells illustrates the establishment of bTRM. a Representative contour plots show the expression pattern of KLRG1 along with the percentage of CD103+ T cells within the infected brains of WT and PD-1 KO mice at 7 and 30 dpi. b Representative flow cytometric analysis of CD127 expression on gated CD8+ T cells at the indicated time points. c Pooled data show the number (mean ± SD) of TRM cells within the brain of WT and PD-1 KO animals at 30 dpi from two independent experiments using two to three animals per group/time points. **p < 0.001 WT versus PD-1 KO at 30 dpi

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