Fig. 4

Correlations between UMSARS clinical scores and cytokine levels in MSA-C patients. a Heatmap analysis of correlations between cytokine levels and UMSARS part 1/part 2. R values of Pearson’s correlation coefficient analysis are divided into quintiles, and p values calculated using one-way ANOVA are indicated as a heatmap. Among the 27 cytokines studied, IL-8 and IL-1β showed correlations with UMSARS scores. b, c Linear regression analysis between IL-1β and UMSARS part 1 (R = 0.43, p = 0.0558) (b), and between IL-8 and UMSARS part 2 (R = 0.61, p = 0.0042) (c). IL: interleukin, MSA-C: multiple system atrophy cerebellar-type, UMSARS: Unified Multiple System Atrophy Rating Scale