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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: YY-1224, a terpene trilactone-strengthened Ginkgo biloba, attenuates neurodegenerative changes induced by β-amyloid (1-42) or double transgenic overexpression of APP and PS1 via inhibition of cyclooxygenase-2

Fig. 1

Experimental design for evaluating the effects of YY-1224 or Gb on learning impairments in mice. a Effects of YY-1224 or Gb on Aβ (1-42)-induced memory impairment in COX-2 (+/+) and COX-2 (−/−) mice (Figs. 2, 3, 4, 5, 6, 7, and 8). Mice received YY-1224 or Gb for 14 consecutive days [7 days before Aβ (1-42) i.c.v. infusion and 7 days period of memory assessment after Aβ (1-42) i.c.v. infusion]. b Effects of meloxicam on the pharmacological activity of YY-1224 or Gb in response to neurotoxic changes (Figs. 9, 10, 11, 12, and 13) in APP/PS1 Tg mice. Mice received YY-1224 or Gb with or without meloxicam 90 consecutive days and additional 5-day period of memory assessment

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Journal of Neuroinflammation

ISSN: 1742-2094