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Fig. 13 | Journal of Neuroinflammation

Fig. 13

From: YY-1224, a terpene trilactone-strengthened Ginkgo biloba, attenuates neurodegenerative changes induced by β-amyloid (1-42) or double transgenic overexpression of APP and PS1 via inhibition of cyclooxygenase-2

Fig. 13

Activity of YY-1224 (YY) or Gb on mRNA expressions of microglial phenotype in the hippocampus. a–c Effect of meloxicam on the pharmacological activity of YY or Gb in response to CD16 (a), CD32 (b), and CD86 (c) mRNA expressions of M1 phenotype microglia/macrophages. d, e Effect of meloxicam on the pharmacological activity of YY or Gb in response to YM1 (d) and CD206 (e) mRNA expressions of M2 phenotype microglia/macrophages. Veh vehicle for YY or Gb (10% tween-80 in sterile saline). Each value is the mean ± S.E.M of five animals. # P < 0.01 vs. vehicle + 0.5% Na-CMC; &P < 0.05, &&P < 0.01 vs. Gb + 0.5% Na-CMC (two-way ANOVA was followed by Fisher’s LSD pairwise comparisons)

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Journal of Neuroinflammation

ISSN: 1742-2094