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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: YY-1224, a terpene trilactone-strengthened Ginkgo biloba, attenuates neurodegenerative changes induced by β-amyloid (1-42) or double transgenic overexpression of APP and PS1 via inhibition of cyclooxygenase-2

Fig. 5

Effects of YY-1224 (YY) or Gb on Aβ (1-42)-induced PAF-AH mRNA levels in the hippocampus. a Changes in PAF-AH I α1 mRNA expression. b Changes in PAF-AH I α2 mRNA expression. c Changes in PAF-AH I LIS1 mRNA expression. d Changes in PAF-AH II mRNA expression. Veh vehicle for YY or Gb (10% tween-80 in sterile saline). Each value is the mean ± S.E.M of six animals. *P < 0.01 vs. COX-2 (+/+) mice treated with vehicle + Aβ (42-1); # P < 0.01 vs. COX-2 (+/+) mice treated with vehicle + Aβ (1-42); &P < 0.05 vs. COX-2 (+/+) mice treated with Gb + Aβ (1-42) (three-way ANOVA was followed by Fisher’s LSD pairwise comparisons)

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Journal of Neuroinflammation

ISSN: 1742-2094