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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: YY-1224, a terpene trilactone-strengthened Ginkgo biloba, attenuates neurodegenerative changes induced by β-amyloid (1-42) or double transgenic overexpression of APP and PS1 via inhibition of cyclooxygenase-2

Fig. 9

Activity of YY-1224 (YY) or Gb on memory impairment and Aβ deposition in APP/PS1 Tg mice. a Effects of meloxicam on the pharmacological activity of YY or Gb in response to Y-maze performance and b novel object recognition. c, d Effect of meloxicam on the pharmacological activity of YY or Gb in response to Aβ-immunoreactivity in the hippocampus (c) and cortex (d). Veh vehicle for YY or Gb (10% tween-80 in sterile saline). Each value is the mean ± S.E.M of 10 (a, b) or 5 (c, d) animals. # P < 0.05, ## P < 0.01 vs. vehicle + 0.5% Na-CMC; & P < 0.05 vs. Gb + 0.5% Na-CMC (two-way ANOVA was followed by Fisher’s LSD pairwise comparisons). Scale bar = 200 μm

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Journal of Neuroinflammation

ISSN: 1742-2094